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KMID : 0370220140580060357
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Yakhak Hoeji
2014 Volume.58 No. 6 p.357 ~ p.363
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Compared Anti-inflammatory Activity of Euonymus alatus and Euonymus alatus for. ciliatodentatus (Franch. & Sav.) Hiyama Extract on Macrop
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Kim Jeong-Hwa
Oh Su-Yeon
Han Ju-Hwan
Lee Gooi-Yong
An Chan-Ki
Hwang Bang-Yeon
Lee Jae-Kwon
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Abstract
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Euonymus alatus (EAE) and Euonymus alatus for. ciliatodentatus (Franch. & Sav.) Hiyama (EACHE) belong to the Celastraceae family and are one of the medicinal herbs used in traditional medicine as a therapeutic agent for blood circulation diseases. In this study, we prepared leaves methanolic extract of EAE (L-EAE), twigs methanolic extract of EAE (T-EAE), leaves methanolic extract of EACHE (L-EACHE) and twigs methanolic extract of EACHE (T-EACHE), and compared their anti-inflammatory activities. To analyze the anti-inflammatory activities, Raw 264.7 cells were used, since they are immature-macrophages and easily matured by lipopolysaccharide (LPS) stimulation. All extracts showed anti-inflammatory activities in the activated Raw 264.7 cells. That is, we showed that L-EACHE and T-EACHE are potent inhibitors of the production of nitric oxide and pro-inflammatory cytokines. These results are expected to serve as a guide for future studies on the ability of Celastraceae family to inhibit acute and chronic inflammatory diseases.
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KEYWORD
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Euonymus alatus, Euonymus alatus for. ciliatodentatus (Franch. & Sav.) Hiyama, macrophage, anti-inflammation
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